Everything about Ansamycin totally explained
Ansamycins is a family of secondary metabolites that show
antimicrobial activity against many
gram-positive and some
gram-negative bacteria and includes various compounds among which:
streptovaricins and
rifamycins . In addition, these compounds demonstrate antiviral activity towards bacteriophages and
poxviruses.
Structure
They are named ansamycins—
ansa from the Latin for handle—because of their unique structure which comprises an aromatic moiety bridged by an aliphatic chain . The main difference between various derivatives of ansamycins is the aromatic moiety, which can be a
naphthalene ring or a
naphthoquinone ring as in
rifamycin and
naphthomycin .
Another variation comprises benzene or a benzoquinone ring system as in geldanamycin or ansamitocin. Ansamycins were first discovered in 1959 by Sensi et al from
Amycolatopsis mediterranei, an Actinomycete.
Examples
Rifamycins are a subclass of ansamycins with high potency against mycobacterial activity. This resulted in their wide use in the treatment of
tuberculosis,
leprosy, and AIDS-related mycobacterial infections. Since then various analogues have been isolated from other prokaryotes.
Further Information
Get more info on 'Ansamycin'.
|
External Link Exchanges
Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:
<a href="http://ansamycin.totallyexplained.com">Ansamycin Totally Explained</a>
Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned. |
